DIN Standards Committee Paper, board and pulps
DIN EN 16418
Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2); German version EN 16418:2014
Papier und Pappe - Bestimmung der Zytotoxizität von wässrigen Extrakten unter Verwendung einer metabolisch kompetenten Hepatom-Zelllinie (HepG2); Deutsche Fassung EN 16418:2014
Overview
This document (EN 16418:2014) has been prepared by Technical Committee CEN/TC 172 "Pulp, paper and board", the secretariat of which is held by DIN (Germany). This European Standard specifies a test method for the laboratory assessment of the potential cytotoxic effect of paper and board intended to come into contact with foodstuffs using specifically the HepG2 cell line. Compared to the EN 15845, HepG2 cells are more representative of a human oral exposure to xenobiotics, due to the presence in the cells of phase I, II and III enzymes of the metabolism.
Document: references other documents
Responsible national committee
NA 074-02-01 AA - Chemical-technological test methods for paper, board, pulps and chemical pulp
